Abstract
Background
Helicobacter pylori
(HP) has immunomodulatory properties, but its relationship with tuberculosis (TB) severity and outcomes remains uncertain. We evaluated the association between HP infection and TB severity and explored factors associated with HP coinfection and TB treatment outcomes.
Methods
We enrolled adults (≥ 18 years) with drug‐sensitive, newly diagnosed, bacteriologically confirmed pulmonary TB from two public clinics in Uganda. HP infection was determined using stool antigen testing. Severe TB was defined as GeneXpert cycle threshold 71 (radiological). Treatment outcomes were determined ≥ 7 months after treatment initiation.
Results
Among 200 participants, 67 (33.5%) were HP positive. Severe radiological TB was more frequent among HP‐positive participants (34.8% vs. 22.1%,
p
= 0.060). Severe clinical (14.9% vs. 11.3%,
p
= 0.549) and microbiological TB (40.0% vs. 33.8%,
p
= 0.856) were also more frequent in HP. HP was not significantly associated with severe radiological (adjusted prevalence ratio [aPR] 1.56; 95% CI 0.96–2.53,
p
= 0.074), clinical (aPR 1.17; 95% CI 0.53–2.60,
p
= 0.694), or microbiological TB (aPR 1.14; 95% CI 0.80–1.63,
p
= 0.462). HP coinfection was independently associated with rural residence (aPR 1.61; 95% CI 1.04–2.47,
p
= 0.031), anorexia (aPR 1.72; 95% CI 1.01–2.90,
p
= 0.045), and lower diastolic blood pressure (aPR 0.98; 95% CI 0.96–1.00,
p
= 0.013). TB treatment success was similar among those with and without HP (95.5% vs. 95.5%,
p
= 0.180).
Conclusion
HP was not significantly associated with TB severity or outcomes, though a trend toward greater radiological severity warrants further investigation in larger, prospective studies.