Abstract
Abstract
Background:
Previous studies have shown an increased risk of second primary malignancies (SPM) among diffuse large B-cell lymphoma (DLBCL) survivors; however, this has not been comprehensively examined by race/ethnicity.
Methods:
From 17 US population–based Surveillance, Epidemiology, and End Results (SEER) program cancer registry areas, we identified 68,358 ≥ 12-month DLBCL survivors diagnosed between 2000 and 2022. Standardized incidence ratios (SIR) and accompanying 95% confidence intervals (CI) quantified SPM risk that occurred ≥12-month after DLBCL by race/ethnicity.
Results:
Overall, we observed 6,261 SPMs after DLBCL representing a 1.2-fold significantly increased risk (95% CI, 1.16–1.22) compared with the general SEER population and an excess of 23 cases/10,000 person-years. SPM risk varied significantly by race/ethnicity, with Asian/Pacific Islanders and Hispanics presenting higher overall risk compared with the White or Black patients (Pheterogeneity
Conclusions:
We observed substantial disparities in SPM risk by race/ethnicity, with patients belonging to minority groups experiencing higher risks.
Impact:
SPMs have emerged as an important challenge for DLBCL survivors; therefore, further research to understand drivers of this observed racial/ethnic heterogeneity is warranted.