Abstract
Purpose
To examine both resting-state and task-related electroencephalography (EEG) changes associated with visual processing in glaucoma.Methods
Thirty glaucoma patients (mean age, 63 ± 8.26 years; visual field mean deviation, -15.41 ± 6.34 dB) and 28 age-matched controls (62.86 ± 9.19 years) underwent resting-state EEG for 3 minutes under eyes-open and eyes-closed conditions. Alpha suppression, calculated as the difference between conditions, was assessed as a measure of cognitive state transition capacity. Visual evoked potentials (VEPs) were recorded using a 64-channel EEG system during a checkerboard reversal task under monocular and binocular viewing.Results
Resting-state EEG revealed that significantly reduced alpha suppression was highly specific to a high-alpha subband (10.0-12.9 Hz; P Conclusions
Both resting-state and task-related EEG measures differed between the glaucoma and control groups, indicating alterations in cortical activity and visual-pathway responses. Specifically, the localized high alpha modulation deficit suggests altered top-down visual network dynamics in glaucoma.