Abstract
Objectives
To compare anatomical and clinical outcomes of mechanochemical ablation (MOCA; ClariVein®) and cyanoacrylate glue closure (CAG; VenaSeal™) for the treatment of incompetent great saphenous veins (GSV) and small saphenous veins (SSV) in patients classified as CEAP C2–C4, with follow-up to 3 years.
Methods
Retrospective analysis of a prospectively maintained single-centre, single-operator database. Allocation to MOCA or CAG followed anatomical suitability and patient preference. Duplex follow-up was at 3 and 8 weeks and 6, 12, 24 and 36 months. The primary endpoint was complete occlusion. The venous segment was the unit of analysis; Kaplan–Meier estimates were compared by log-rank test and proportions by Fisher’s exact test.
Results
A total of 214 venous segments were treated with MOCA (196 GSV, 18 SSV) and 161 with CAG (148 GSV, 13 SSV). Cohorts were comparable in vein diameter and segment length; CAG patients were older (median 45 vs 39 years). GSV occlusion at 24 months was 94.4% (95% CI 90.2–96.8) for MOCA and 96.6% (95% CI 92.3–98.5) for CAG (Fisher
p
= .441; log-rank
p
= .329). SSV occlusion was 77.8% (95% CI 54.8–91.0) in 18 MOCA segments and 100% (95% CI 77.2–100) in 13 CAG segments (Fisher
p
= .120; log-rank
p
= .075); with only 31 SSV segments the estimate is imprecise, and the non-significant result is not evidence of equivalence. Three-year results were identical to 24-month data. Symptom improvement was documented in both groups without obvious deterioration in association with late recanalisation; assessment was qualitative, without a validated instrument.
Conclusions
CAG showed numerically higher GSV and SSV occlusion than MOCA at two and 3 years, but no difference reached statistical significance and the cohorts were not randomised. No obvious symptomatic deterioration was documented with late MOCA recanalisation, supporting a clinically led rather than duplex-led re-treatment strategy. Adequately powered randomised trials with 3-year follow-up are required.