Comparison of Blood Glucose Values Used for Impending Non-Severe Hypoglycemia Management with Corresponding Continuous Glucose Monitoring Data in Type 1 Diabetes: A Secondary Analysis of the REVERSIBLE Trial

Background: To assess continuous glucose monitoring (CGM) data corresponding to blood glucose (BG) values used for impending non-severe (NS) hypoglycemia management in people living with type 1 diabetes (PwTID). Methods: We performed a secondary analysis of the REVERSIBLE trial, a three-arm open-label crossover study assessing the efficacy of 16 g oral carbohydrates (CHO) for preventing NS hypoglycemia at different BG levels: ® ) were compared with BG to assess their variances and mean absolute relative differences (MARDs). Results: In all three arms CGM values overestimated BG levels ( P 180 mg/dL; 10 mmol/L). Conclusion: When using CGM, PwTID may need to treat or prevent NS hypoglycemia at a higher threshold than 72 mg/dL (4.0 mmol/L) and 80 mg/dL (4.5 mmol/L), respectively.