Abstract
Background
Cardiovascular disease (CVD) is more common in those with metabolic dysfunction-associated steatotic liver disease (MASLD). Although the triglyceride-glucose index (TyG) and its composite indices are straightforward indicators of insulin resistance, it is yet unknown how they relate to the risk of CVD in the MASLD population.
Objectives
To explore the correlation of TyG and TyG-waist-to-height ratio (TyG-WHtR) with cardiovascular disease risk in the MASLD population.
Design
This was a population-based cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES) 1999–2023.
Methods
Adults with MASLD were included using cross-sectional data from the National Health and Nutrition Examination Survey (NHANES). ROC curve assessments, subgroup analyses, smooth curve fitting, and multivariate logistic regression were carried out.
Results
Among 1,860 participants, TyG (OR=1.27) and TyG-WHtR (OR=1.20) were independently associated with elevated CVD risk after full covariate adjustment (all
P
Conclusion
TyG and TyG-WHtR showed positive associations with CVD in patients with MASLD, with a remarkable threshold effect observed for TyG. Both indices are simple auxiliary markers to screen high-risk subgroups during population epidemiological surveys.