Association of CETP TaqI and APOE polymorphisms with type II diabetes mellitus in North Indians: a case control study

Abstract Background Genetic variants of proteins involved in lipid metabolism may play an important role in determining the susceptibility for complications associated with type II diabetes mellitus (T2DM). Goal of the present study was to determine the association of cholesteryl ester transfer proteinTaqI B, D442G, andAPOE HhaI polymorphisms with T2DM and its complications. Methods Study subjects were 136 patients and 264 healthy controls. All polymorphisms were detected using PCR-RFLP and statistical analysis done with χ2test and ANOVA. Results AlthoughCETP TaqI B polymorphism was not associated with the T2DM, yet B1B2 genotype was significantly (p = 0.028) associated with high risk of hypertension in diabetic patients (OR = 3.068, 95% CI 1.183–7.958). In North Indians D442G variation inCETPgene was found to be absent. Frequency ofAPOE HhaIpolymorphism was also not different between patients and controls. In diabetic patients having neuropathy and retinopathy significantly different levels of total-cholesterol [(p = 0.001) and (p = 0.029) respectively] and LDL-cholesterol [(p = 0.001) and (p = 0.001) respectively] were observed when compared to patients with T2DM only. However, lipid levels did not show any correlation with theCETP TaqI B andAPOE HhaI genetic polymorphisms. Conclusion CETP TaqI B andAPOE HhaI polymorphism may not be associated with type II diabetes mellitus in North Indian population, howeverCETP TaqI B polymorphism may be associated with hypertension along with T2DM.