Life and death of lymphocytes: a role in immunesenescence

Houfen Su; Ruifen Bi; Sudhanshu Agrawal; Sastry V. S. Gollapudi

doi:10.1186/1742-4933-2-12

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Life and death of lymphocytes: a role in immunesenescence

Houfen Su, Ruifen Bi, Sudhanshu Agrawal, Sastry V. S. Gollapudi

Immunity & Ageing2005doi:10.1186/1742-4933-2-12

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Abstract

Abstract Human aging is associated with progressive decline in immune functions, increased frequency of infections. Among immune functions, a decline in T cell functions during aging predominates. In this review, we will discuss the molecular signaling in two major pathways of apoptosis, namely death receptor pathway and mitochondrial pathway, and their alterations in both T and B lymphocytes in human aging with a special emphasis on naïve and different memory subsets of CD8+ T cells. We will also discuss a possible role of lymphocyte apoptosis in immune senescence.

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Authors

Houfen Su#2 Ruifen Bi#3 Sudhanshu Agrawal#4 Sastry V. S. Gollapudi#5

Institutions

University of California, Irvine

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External reference records

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Life and death of lymphocytes: a role in immunesenescence

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