Regulation of TGF-β receptor activity

Ye-Guang Chen

doi:10.1186/2045-3701-2-9

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Regulation of TGF-β receptor activity

Ye-Guang Chen

Cell & Bioscience2012doi:10.1186/2045-3701-2-9

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Abstract

TGF-β signaling regulates diverse cellular processes, including cell proliferation, differentiation, apoptosis, cell plasticity and migration. Its dysfunctions can result in various kinds of diseases, such as cancer and tissue fibrosis. TGF-β signaling is tightly regulated at different levels along the pathway, and modulation of TGF-β receptor activity is a critical step for signaling regulation. This review focuses on our recent understanding of regulation of TGF-β receptor activity.

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Ye-Guang Chen#2

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Referenced works

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Mechanism and Regulation of Nucleocytoplasmic Trafficking of Smad

2011 · 0 citations

Partners in crime: the TGFβ and MAPK pathways in cancer progression

2011 · 0 citations

Non-degradative ubiquitination in Smad-dependent TGF-beta signaling

2011 · 0 citations

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10.1186/2045-3701-1-40

10.1186/2045-3701-1-43

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10.1242/jcs.02554

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Regulation of TGF-β receptor activity

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