Personalized medicine in patients with Osteogenesis imperfecta

Results With this change of therapy we were able to reduce bone resorption to the normal range [2]. After two years of treatment both patients show an increase of bone mineral density of the lumbar spine with a z-score from – 2.4 to -2.0 and -4.3 to 2.5 respectively and an increase of projected vertebral area L2 – L4 [mm2] from 1670 to 2152 and from 1424 to 1528. No severe side effects were seen and the drop of serum calcium after the subcutaneous injection could be treated by oral calcium supplementation. Conclusion Clinical observation and molecular analysis lead to a new understanding of OI VI and to a more specific therapeutic approach. The new therapy resulted in a better therapeutic effect and is a striking example of a fast transfer from basic research to therapeutic use.