Integrated genomics elucidates relative spatial homogeneity of embryonal brain tumors
Marc Remke, Florence M.G. Cavalli, A. Sorana Morrissy, David T.W. Jones, Roger J. Packer, Éric Bouffet, Gary D. Bader, Arndt Borkhardt, Stefan Michael Pfister, Nada Jabado, Marco A. Marra
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Abstract
Genome-wide profiling and next-generation based sequencing studies have dramatically improved our understanding of embryonal brain tumor (EBT) biology in the recent years. However, the vast majority of these studies are based on the assumption that single biopsies are representative for the entire primary tumor. Intratumor heterogeneity constitutes a common phenomenon previously described in renal cell carcinoma (RCC) and high-grade glioma (HGG). Highly disparate molecular profiles of spatially separated tumor areas within the same tumor may preclude development of molecularly targeted therapies based on single tumor biopsies.
