Quantitative stress echocardiography in pediatric patients with type-1 diabetes mellitus

We included 40 patients with T1DM (aged 11.53 ± 3.1 years) and 44 sex-matched healthy controls (11.43 ± 2.9 years; p = 0.91). Conventional and quantitative echocardiography was performed both at rest and during physical exercise on a bicycle. Myocardial strain and strain rate were measured using speckle tracking echocardiography. Children with T1DM had increased myocardial contractility both at rest and at all levels of physical stress testing when compared to healthy volunteers. At rest, T1DM patients had significantly higher circumferential strain rate (-2.05 ± 0.35 s) than healthy controls (-1.86 ± 0.25 s; p = 0.016). During exercise, diabetic children showed more negative values for longitudinal strain rate (-2.59 ± 0.47 s) than healthy controls (-2.32 ± 0.41 s; p = 0.021). Furthermore, in T1DM patients, disease duration inversely correlated with myocardial strain rate and serum HbA1c levels correlated with strain both at rest and during stress testing. Long-term impairment of cardiac function in diabetic cardiomyopathy may be preceded by a transient phase of increased myocardial contractility early in the course of T1DM. The extent of hyperglycemia in childhood correlates with the alteration of myocardial contractility.