Abstract
Robot-assisted minimally invasive surgery provides stable visualisation and manipulation, but direct access to local tissue state remains limited. Lesion boundaries, mechanics, molecular activity and microenvironmental changes are often inferred from conventional feedback. This review evaluates how nano-enabled imaging, flexible and local sensing, and micro/nanorobotic intervention may extend signals and localised actions in robot-assisted procedures. We organise the evidence along an information-flow framework: signal acquisition, processing or computational interpretation, task-relevant state estimation, conversion into a decision variable or control-relevant input, and feedback-guided robotic action. Processing may involve calibration, signal processing, computational modelling, conventional machine learning, deep learning or artificial intelligence (AI)-based methods. The evidence reviewed is strongest for localised signal acquisition and supervised intervention. Selected forms of computational interpretation have been demonstrated, and localisation- or motion-derived geometric states enter feedback controllers in some systems. By contrast, biochemical, spectral, tactile and physiological states are usually displayed, analysed offline or returned through human-facing feedback; they rarely modify an online surgical controller. Closed-loop navigation in phantoms, surrogate-device studies and constrained navigation autonomy therefore represent partial control capabilities, not clinically relevant surgical autonomy. The principal missing transitions are robust validation of task-relevant tissue states, uncertainty-aware conversion of those states into control inputs, and safe action within realistic surgical workflows. Near-term clinical use is more likely to centre on bounded nano-enabled sensing or intervention modules embedded within supervised procedures. Progress towards bounded task autonomy will require reproducibility, material safety, workflow compatibility, explicit human supervision and prospective evidence of patient and task benefits.