Abstract
Objective
To investigate the clinical significance of serum magnesium in non-diabetic mellitus (non-DM), diabetes mellitus (DM) and diabetic retinopathy (DR). Moreover, to assess magnesium concentration in DR mice models.Methods
Baseline data from 150 patients per group (non-DM, DM, DR) comprised demographics, cardiovascular-metabolic profiles, electrolytes, and systemic immune-inflammatory were collected and analyzed. Logistic regression analysis was used to screen influencing factors for DR. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic utility of hemoglobin A1c (HbA1c) and magnesium. Magnesium concentration in both serum and retinal tissues of DR mice were quantified via the methylthymol blue assay.Results
Compared with the non-DM group, the DM group had lower age and blood pressure levels (P Conclusion
Patients with DR had longer disease duration, elevated HbA1c levels and decreased serum magnesium concentrations. Combined detection of serum magnesium and HbA1c can significantly improve the diagnostic performance of DR.