Abstract
Abstract
Background
Natural products use for arthritis treatment is gaining importance in the medical worldt. Various studies reports medical importance of
Melastoma malabathricum Linn
. (
MM
) (Melastomataceae), also known as “putki,” has a broad range of health benefits, for its free radical scavenging constituents. The current investigation scrutinizes the antioxidant and anti-inflammatory effect of
MM
against adjuvant-induced arthritis in experimental rats.
Methods
High-performance thin layer chromatography (HPTLC) was used for estimation of phytochemical-constituents present in the
MM
extract. Protective effect of
MM
extract in Wistar rats was estimated using CFA-induced model. The rats were divided into different groups with six rats in each group. All animals received oral administration of
MM
and indomethacin for 28 days. The body weight and arthritic score were scrutinized at regular intervals. At the end of experimental protocol, the rats were sacrificed, and blood samples were used for antioxidant, hematological parameters, pro-inflammatory and inflammatory mediator, respectively. Histopathological observation was used to evaluate the protective effect of
MM
extract.
Result & discussion
Current study confirmed the preventive effect of
MM
against adjuvant-induced paw edema, paw redness and arthritic progression.
MM
significantly (
P
MM
in CFA induced arthritis. Histological analyses of joints of rats showed a reduction in the synovial hyperplasia and mononuclear infiltration in the
MM
treated group which provides evidence for the antiarthritic effect of
MM
.
Conclusion
From above parameters our study states that the
MM
is capable of restraining the alteration produced via adjuvant-induced arthritis in aminals. The repressing effect of
MM
could be attributed, at least in part, to antioxidant, hematological and anti-inflammatory effect.
Graphical abstract
Figure Caption:
Melastoma Malabathricum
Linn Attenuates Complete Freund’s Adjuvant-Induced Chronic Inflammation in Wistar rats by Inflammation Response
Open public full textRights: ALLOWED · cc-by · Source: journal-auto-sync:external:CROSSREF_ISSN