Abstract
Abstract Objective This study aims to evaluate the cardioprotective effects of intravenous lipid emulsion (ILE) in combination with hemoperfusion (HP) on myocardial injury in patients with acute organophosphorus pesticide poisoning (AOPP). Methods A retrospective analysis was conducted involving 96 patients with confirmed AOPP between January 2016 and December 2023. Patients were allocated into three clearly defined treatment groups of equal size (n = 32 each): (1) the control group, receiving standardized conventional treatment; (2) the HP group, receiving two sessions of HP in addition to conventional therapy; and (3) the combined treatment group, receiving 20% medium/long-chain fat emulsion injection in conjunction with both conventional therapy and HP, following protocol-specific regimens. Clinical manifestations were documented across all groups. Biochemical markers, including serum levels of cholinesterase (ChE), creatine kinase-Mb (CK-MB), cardiac troponin I (cTnI), and N-terminal pro B-type natriuretic peptide (NT-proBNP) were measured on day 1 and day 5.Continuous electrocardiographic monitoring and transthoracic echocardiography were also performed. Results Post-treatment analyses revealed significantly elevated ChE levels and reduced levels of CK-MB, cTnI, and NT-proBNP in both the HP and combined treatment groups compared to the control group (p 0.05). Conclusion The combination of intravenous lipid emulsion and HP in patients with AOPP was associated with reduced myocardial injury and improved cardiac biomarker profiles, suggesting a protective effect on myocardial tissue.