Energy cost of walking and functional aerobic capacity during moderate intensity exercise in adults with obstructive sleep apnea: a cross-sectional study

Abstract Background Autonomic dysregulation associated with obstructive sleep apnea (OSA) may limit cardiopulmonary responses to exercise, which, in turn, may impair functional aerobic capacity (FAC) and walking economy. We aimed to characterize walking economy and FAC in OSA patients compared with healthy adults (non-OSA) and examine their relationship with OSA severity (apnea-hypopnea index [AHI]). Methods A total of 26 adults (OSA, n  = 13; non-OSA, n  = 13) participated in this cross-sectional study. In this study, the participants with OSA were between the ages of 25 and 60 years, with a body mass index of 25 kg/m 2 to 39 kg/m 2 , and who had undergone a recent third-party sleep study with an AHI of 5 or greater. Participants completed a maximal integrated cardiopulmonary exercise test, three separate exercise bouts of constant work rate (CWR) treadmill test at 85% of anaerobic threshold (AT), and a 10-min walk test (10MWT). Multiple linear regression analysis corrected for weight, age, and BMI were performed to examine the associations. Results There were significant differences between OSA and non-OSA participants in VO 2peak (29.7 ± 5.6 mL/kg/min vs. 37.5 ± 6.5 mL/kg/min, p  = 0.03) and Net VO 2 during CWR (12.7 ± 5 vs.19 ± 6 mL/kg/min, p  = 0.02). The 10MWT speed and distance were significantly lower in the OSA group (all p  p  R 2  = 0.85, p  R 2  = 87, p  2 at anaerobic threshold ( R 2  = 0.92, p   Conclusions The findings of this study show that patients with OSA have reduced FAC and a higher energy cost of walking. AHI explained 87% of variance in the energy cost of walking during the 10MWT. The results suggest that individuals with more severe obstructive sleep apnea experience greater impairment in functional performance.