Hepato-morpholoy and biochemical studies on the liver of albino rats after exposure to glyphosate-Roundup®

Abstract Background The object of this work was to evaluate of the hepatic effects of the herbicides glyphosate-Roundup® by different doses in both sexes of albino rats. Methods Forty animals divided into four groups with ten animals for each (both sexes) were treated orally with vehicle (controls) and 25, 50, and 100 mg/kg bwt of glyphosate-Roundup® (treated groups) for 15 days daily. Results The most conspicuous changes occurred on the liver treated groups due to glyphosate toxicity were the increase of enzymes activities of ALT and AST, cellular infiltration, many signs of nucleus degeneration, focal necrosis, rarified cytoplasm, disorganization of cellular organelles, and deposition of lipid droplets. The increase in the amount of collagenous fibers and the number of the mast cell were also observed. Conclusion Our results indicated that the administration of glyphosate-Roundup® in different doses may cause adverse effects on the histopathological, ultrastructure, and biochemical alternations on the liver of the albino rats.