Abstract
Abstract
Background
Evidence for alteplase 4.5–24 h after acute ischemic stroke (AIS) onset remains limited in routine practice. We examined associations between late-window intravenous thrombolysis (IVT) and discharge outcomes in selected patients.
Methods
We analyzed China Stroke Center Alliance patients arriving 4–23.5 h after onset. Alteplase-treated patients were matched 1:1 to non-IVT patients using propensity scores. The primary outcome was modified Rankin Scale (mRS) 0–1 at discharge. Secondary and safety outcomes included mRS 0–2, registry-recorded in-hospital intracranial hemorrhage (ICH), mortality, discharge against medical advice (DAMA), and mortality or DAMA.
Results
Among 137,157 eligible AIS patients, 874 received IVT and were matched to 874 non-IVT patients. Median onset-to-needle time was 6.05 h (interquartile range 5.12–10.04); 48.4%, 23.7%, 6.6%, and 21.3% were treated at 4.5-p
p
= 0.002). In-hospital ICH was more frequent (1.7% vs. 0.6%, OR 3.04, 95% CI, 1.10–8.39,
p
= 0.03), whereas DAMA was less frequent (5.7% vs. 8.8%, OR 0.63, 95% CI, 0.44–0.92,
p
= 0.02). Length of hospital stay, mortality, and mortality or DAMA did not differ significantly.
Conclusions
Late-window alteplase was associated with better discharge function but more registry-recorded ICH in selected patients. Because symptomatic status, hemorrhage subtype, severity, and fatality were unavailable, hemorrhagic safety remains incompletely characterized. These observational findings require cautious interpretation.