Evaluation of liver parenchymal changes in patients with reduced left ventricular ejection fraction using cardiac MRI T1 mapping and extracellular volume fraction

Abstract Background and objectives Congestive hepatopathy (CH) is a diffuse parenchymal liver disease resulting from chronic passive congestion due to cardiac pathology. This retrospective cross-sectional study aims to evaluate hepatic congestion in patients with left ventricular ejection fraction (LVEF) Methods We analyzed 103 patients with LVEF Results Liver pre-contrast T1 ( p p =0.032), and ECV ( p p p p =0.012). Liver pre-contrast T1 yielded the highest AUC (0.949) with a cutoff of 608.16 ms (sensitivity 88.3%, specificity 95.0%), outperforming all myocardial and other liver parameters. Native liver T1 correlated with stroke volume index (ρ=− 0.461), left ventricular end-diastolic (ρ=0.301) and end-systolic indexes (ρ=0.572), NT-proBNP (ρ=0.324), and GGT (ρ=0.360) (all p Conclusions Routine CMR pre-contrast liver T1 mapping facilitates early detection and quantification of CH in patients with reduced LVEF, potentially preceding overt clinical or laboratory abnormalities.