Abstract
Тhe aim of our work was to find out the peculiarities of changes ofendogenous intoxication indices in guinea pig blood during theformation of combined pathology - experimental contact dermatitis and experimental pneumonia and correction of their disorders with thiotriazoline.The paper found a gradual increase in the molecules of mediummass and erythrocyte index of intoxication in guinea pig serum with experimental contact dermatitis and experimental pneumonia with the highest degree of expression on the 18thday of the experiment, and this may be may indicate the development of endogenous intoxication of the animal body. At the same time, the use of the drug thiotriazoline caused the decrease of the studied indicators, which gives grounds to stateits positive effect on certain markers of endogenous intoxicationand the feasibility of further research.