When two signals are better than one: Synergistic control of erythropoiesis

Nicola K. Wilson

doi:10.1371/journal.pbio.3003512

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When two signals are better than one: Synergistic control of erythropoiesis

Nicola K. Wilson

PLOS Biology2025doi:10.1371/journal.pbio.3003512

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Abstract

Red blood cell production is one of the most dynamic processes, yet the underlying mechanisms responsible are only partially understood. A new study in PLOS Biology suggests a broadly applicable mechanism able to balance the maintenance of the steady-state and effective stress response.

Authors

Nicola K. Wilson#1

Institutions

University of Cambridge Wellcome/MRC Cambridge Stem Cell Institute

Provenance

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External reference records

IL-17 stimulates erythropoiesis in vivo by amplifying the response of erythroid progenitors to erythropoietin

2025

Molecular and cellular mechanisms that regulate human erythropoiesis

10.1182/blood.2021011044 · 2022

BMP4, SCF, and hypoxia cooperatively regulate the expansion of murine stress erythroid progenitors

10.1182/blood-2006-04-016154 · 2007

BMP4 and Madh5 regulate the erythroid response to acute anemia

10.1182/blood-2004-02-0703 · 2005

The glucocorticoid receptor is required for stress erythropoiesis

10.1101/gad.13.22.2996 · 1999

Population snapshots predict early haematopoietic and erythroid hierarchies

10.1038/nature25741 · 2018

Additional external references

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