Abstract
Abstract
Aim
Omentin-1 is an adipokine associated with insulin sensitivity and inflammatory processes, while the ITLN1 Val109Asp (rs2274907) variant has been implicated in metabolic phenotypes. We investigated its association with circulating omentin-1 and a metaflammatory phenotype in men with type 2 diabetes mellitus (T2DM).
Methods
In this cross-sectional study, 225 men with T2DM were genotyped for ITLN1 Val109Asp (TT, AT, and AA). Anthropometric, glycaemic, insulin-resistance, lipid, inflammatory, and haematological parameters were compared across genotypes. Associations between circulating omentin-1 and metabolic, inflammatory, and haematological parameters were assessed using Spearman correlation. Logistic regression evaluated associations between the variant and obesity under dominant, recessive, and additive models. Receiver operating characteristic analysis assessed discrimination of low circulating omentin-1.
Results
Omentin-1 concentrations decreased progressively from TT to AT to AA genotypes [749.6, 627.9, and 483.2 ng/L, respectively; P Conclusion
ITLN1 Val109Asp was associated with circulating omentin-1 concentrations and a metaflammatory phenotype in men with T2DM, linking genetic variation with a metabolic–inflammatory profile.