Abstract
Abstract
Study aim
This study aims to determine the impact of 4 weeks of moderate aerobic exercise on adiponectin and pancreatic β-cell function in men with type 2 diabetes mellitus (T2DM).
Materials and Methods
Twenty-two men with T2DM who participated in this randomized controlled trial were randomly assigned to trial (
n
= 11) or control (
n
= 11) groups. The trial group took part in 4 weeks of moderate aerobic exercise consisting of three sessions/week of 30 min/day. Variables were measured 30 min before the first session and after the last session, including weight, height, body mass index, insulin, fasting plasma glucose (FPG), adiponectin, and HOMA-β. Independent
t
-tests, Mann–Whitney
U
tests, Wilcoxon signed-rank tests, paired
t
-tests, and Fisher’s exact tests were performed.
Results
Twenty men with T2DM in trial group (
n
= 10) and control group (
n
= 10) were analyzed. There were significant differences in adiponectin levels between the groups after exercise (
p
= 0.003) and in the degree of adiponectin changes between groups (
p
= 0.017). FPG levels between groups was significantly different after exercise (
p
= 0.018). There was no significant difference in HOMA-β levels between the trial and control groups after 4 weeks of exercise (
p
= 0.131). No linearity between adiponectin changes and HOMA-β changes was observed.
Conclusion
Four weeks of moderate aerobic exercise improved adiponectin and glucose uptake. While adiponectin levels increased, β-cell function did not show a significant change as measured by HOMA-β.