Abstract
Histamine – biogenic amine that is synthesized in the human body and acts as a mediator of a number of biological reactions. The extracellular histamine pathway involving enzymes diamine oxidase. Lack activity of this enzyme leads to a syndrome of histamine intolerance and out comes related to the pleiotropic effects of histamine. The article presents the main causes of decreased activity diamine oxidase, typical clinical symptoms that characterize this syndrome, diagnostical go rithm and characteristics of patients. Described as analternative, safe for patient test for diagnosing the syndrome of histamine intolerance – «Histamin 50-Skin- Prick Test». Based on the clinical cases shows modern diagnostic capabilities in specifi c patients with manifestations of allergic pathology. Understanding the pathogenesis of the syndrome of histamine intolerance, research in to the diagnosis of failure diamine oxidase gives opportunities to the choice of effective approaches in the treatment of patients so requires a deep knowledge of physicians of differents pecialties.