Abstract
Two principal problems that exist in pharmaceutics are the non-addressed action of medicines causing negative side effects in the organism and rapid development of drug resistance in treated patients. Here we present examples how drug encapsulation in the polymeric or mineral nanoscale platform can enhance its treatment effect, improve its targeting in the organism, as well as provide the drug with ability to circumvent drug-resistance mechanisms. Thus, such encapsulation makes the drug “smarter” during its action.