Abstract
Diagnostic criteria of chronic coronary artery disease (CAD) with metabolic syndrome (MS) in case of obesity were singled out in the research. Gender and age were considered as well.
Material and methods. 138 patients with MS and II – IIІ degree obesity with a preliminary diagnosis of CAD were examined. The first group was represented by individuals aged 28-40, the second group was represented by patients aged 40-70. The third group was represented by 30-40-year old female patients and the fourth group – by 40-70-year-old female patients. Levels of prolactin, cortisol, free thyroxine (fT4), thyroid-stimulating hormone (TSH), lipid spectrum, were determined for all patients. Ultrasonography of the heart was also taken into account.
According to the results of the study of lipid metabolism, increase of low-density lipoprotein cholesterol (LDL CH), triglycerides (TG), very low-density lipoprotein cholesterol (VLDL CH), total cholesterol (TCH), coefficient of atherosclerosis (CA) and decrease of high-density lipoprotein cholesterol (HDL CH) were observed in patients of 1, 2 and 4 groups.
Results. Left ventricular posterior wall thickness (LVPWT), interventricular septal thickness (IVST), left ventricular end-diastolic size (LVEDS) and left atrium anteroposterior dimension (LA) were enlarged in patients of 1, 2 and 4 groups (diagnosis of chronic CAD was confirmed) according to results of echocardiography.
According to the results of lipid spectrum study, high levels of TG and VLDL were observed in patients of the 3rd group (diagnosis of chronic CAD was not confirmed).
According to ultrasonography results, increased IVST and LA dilatation indicated the development of metabolic cardiopathy in patients of this group.
Increased levels of prolactin, cortisol, and TSH were observed in patients of group 3. An increased of level of TSH was observed in the second and fourth groups, unlike the first group, where the level of TSH was normal.
Prolactin level was within normal limits in groups 1, 2, 4. High levels of TSH and normal levels of cortisol were recorded in groups 2 and 4, in contrast to group 1, which had a normal TSH level and increased cortisol level.
Gender differences in the first and third group: increased TSH and prolactin levels for women of the 3rd group and normal levels of these hormones for men of the 1st group. Increased levels of TSH with normal content of prolactin were observed in the second and fourth groups.
Conclusions. During the estimation of research results, it may be stated that the increased prolactin level in group 3 concurs clinically with the absence of CAD and can serve as a diagnostic marker of this condition.