Abstract
Dear reader, The 21st year of the 21st century will go down in history as the boundary that divided the coronavirus (COVID-19) pandemic and post-pandemic world. It is the efforts of medical academic institutions and the dedicated medical professionals all around the world that have demonstrated a high readiness to overcome the modern challenges of the pandemic that has engulfed all the humanity. The world has received a new vector in the development of science to understand the strategy to combat the "plague" of the 21st century. First, it is the creation of specific prevention of COVID-19 at a record pace: on January 10, 2020, the information on the sequencing of SARS-CoV-2 virus (also known as 2019-nCoV) was received, and on December 11, 2020, vaccination against COVID-19 started among healthcare professionals in the United States. Currently, more than 2 billion people worldwide have been vaccinated against SARS-CoV-2 [1]. No deaths have been reported in the UK for 25 days (as of June 3, 2021), nevertheless changes in the SARS-CoV-2 genome and the emergence of new virus strains continue, and reports from high-incidence regions such as India are still alarming. The pandemic of the SARS-CoV-2 virus, which as of today has infected more than 171 million and killed more than 3.5 million people globally, has been a major test for newer vaccines that differ from the previous ones. The organization and conduct of clinical research are becoming more important than ever. The article by Andriy Cherkas is dedicated to this topic [2]. Pfizer, Moderna, AstraZeneca and Johnson-Johnson vaccines developed and tested in clinical trials were made possible following the results of fundamental research by Katalin Karikó and Drew Weisman, which began almost 30 years ago [2] and ushered in the fifth era of vaccination [3, 4].