Abstract
Background and objectives. Peritoneal relapse (PR) is the most common pattern of gastric cancer (GC) recurrence after radical treatment. Currently, a variety of adjuvant intraperitoneal chemotherapy methods are being tested for their efficacy in reducing the level of PR.
Methods. The radical treatment results of 226 patients with localized and locally-advanced GC have been analyzed. In order to select a group of patients with indications for adjuvant intraperitoneal therapy, a study of independent predictive factors and the development of a predictive PR nomogram for gastric cancer was completed.
Results. As a result of the analysis of about three dozen potential factors in mono- and multivariate analysis, the impact on PR risk was confirmed by 4 independent predictive factors, namely: serosal invasion and its size (HR 9.36, p <0.001), morphological type according to Lauren (HR 5.3, p <0.001), index of regional lymph node involvement (HR 2.23, p = 0.015) and localization of the tumor in the stomach (HR 3.98, p <0,001).
Conclusions. A predictive PR risk nomogram of gastric cancer after radical surgical treatment has been developed based on the identified independent factors, and it is of great clinical importance as a tool for segregating patients who require adjuvant intraperitoneal chemotherapy.