Abstract
Objective. The objective of this study is to investigate the impact of the triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) on the function of the renal allograft.
Materials and Methods. The results of laboratory tests from 77 patients who underwent kidney allotransplantation were analyzed. The first observation group (three months post-surgery) included 50 patients, and the second group (six months post-transplantation) included 32 patients.In each of these groups, a correlation analysis was conducted between the TG/HDL-C ratio and the estimated glomerular filtration rate (eGFR).Each analyzed group was divided into three subgroups based on the TG/HDL-C ratio: subgroup I corresponded to the lowest values, while subgroup III represented the highest. A comparison of glomerular filtration rate (eGFR) was performed between these subgroups.
Results. Correlation analysis in both groups revealed a weak negative relationship between the TG/HDL-C ratio and eGFR. In the first group, Spearman’s and Kendall’s correlation coefficients were r = −0.301 and r = −0.213, respectively, while in the second group, the corresponding values were r = −0.254 and r = −0.162.Additional analysis showed that in the first group, patients with the highest TG/HDL-C ratio values (subgroup III) had significantly lower eGFR levels compared to subgroup I (t = 2.46; p = 0.02). In the second group, no statistically significant differences in eGFR were found between subgroups (t = 1.46; p = 0.15).
Discussion. The mechanisms underlying the reduction in eGFR in the setting of dyslipidemia in renal allografts are likely similar to those observed in native kidneys. Potential pathogenic factors include ischemia-reperfusion injury, immunological responses, and the nephrotoxic effects of immunosuppressive therapy. These factors may enhance the dyslipidemic effect and worsen functional outcomes after allotransplantation. Further studies are required to more precisely determine the clinical significance of these mechanisms. Conclusions. The TG/HDL-C ratio cannot be identified as an independent risk factor for renal allograft dysfunction at 3- and 6-months post-transplantation. Further studies are needed to explore the effect of the TG/HDL-C ratio on transplanted kidney function.