Abstract
The review focused on analyzing clinical and immunological peculiarities in patients with common variable immunodeficiency, with and without manifestations of secondary systemic vasculitis. CVID is a primary immunodeficiency marked by quantitative and functional deficiencies in B and T lymphocytes. However, it is most commonly associated with a deficiency in antibody production. Around 38% of individuals with common variable immunodeficiency develop autoimmune diseases as a result of disrupted immune regulation. The outcomes of the clinical progression analysis and laboratory immunological changes in patient groups being compared are presented. The results suggest an inverse correlation between the reduction in the number and functional activity of T-regulatory lymphocytes in patients with common variable immunodeficiency and the activation of clinical symptoms of secondary systemic vasculitis in these patients, primarily due to the depletion of the immune response’s reserve capabilities. A deeper understanding of the risks associated with the dysregulation of immune surveillance in patients with common variable immunodeficiency and secondary systemic vasculitis will enable the prescription of modern comprehensive replacement and immunopathogenetic therapy.