Abstract
Research on medicinal plants has grown significantly due to their enduring reputation, economic benefits, and sustainability. This review focuses on the climbing plant Diplocyclos palmatus, commonly known as striped cucumber, which belongs to the Cucurbitaceae family. The plant has numerous health benefits, including antioxidant, antibacterial, anti-infective, anti-diabetic, antipyretic, anticancer, antifertility, antithrombotic, antivenom, antidote, and anti-inflammatory properties. It continuously re-examines the morphology, bioactive compounds, and the activity of secondary metabolites using in vitro, in vivo, and in silico approaches for Diplocyclos palmatus. Finally, the reassessment outlines the various analytical techniques, including TLC, FTIR, SEM, GC-MS, HPLC, and LC-MS, while revisiting the traditional applications of Diplocyclos palmatus.