Abstract
Background: Brain diseases, including neurodegenerative disorders such as Alzheimer's disease, represent a significant global health burden with rising prevalence due to aging populations. Cerebronal® (Medicinalis) is a dietary supplement formulated with a proprietary blend of plant extracts, acetyl L-carnitine, nucleotides, vitamins, and antioxidants designed to support brain health and cognitive function.
Objective: This study evaluated the effects of Cerebronal® supplementation during three to six monthsimplementation on biomarkers associated with neurodegeneration and brain regeneration in 54 outpatientsexperiencing memory problems. Hair follicle cells were collected and directly reprogrammed into neurons for analysis of key proteins including total Tau, phosphorylated Tau181, beta-amyloid 42, neurogranin, and VEGF using ELISA assays (Check My Brain®, Omnion Research International).
Results: While total Tau and beta-amyloid levels showed no significant changes, a subgroup of patients with elevated Tau181/total Tau ratios exhibited a significant reduction after supplementation. Additionally, patients with initially low levels of neurogranin and VEGF demonstrated significant increases, indicating potential improvements in synaptic function and neurovascular support.
Novelty: These novel findings suggest that Cerebronal® may beneficially modulate specific molecular markers linked to neurodegeneration and brain repair in vulnerable individuals. In addition, the study highlights the utility of hair follicle-derived neuronal cultures as a minimally invasive tool for monitoring biomarker changes.
Conclusion: Although more research with higher number of participants will be needed, overall, Cerebronal® shows promise as an adjunctive intervention for cognitive health, with quantitatively proven benefits.
Keywords: neurodegenerative disorders, biomarkers, food supplements, Tau, Tau181, beta amyloid, neurogranin, VEGF