Expression of CCr5 on immune cells after eccentric or concentric isokinetic exercise

OBJECTIVE: To compare the expression of C-C Chemokine receptor type 5 (CCr5) on monocytes and T cells in soccer players who were submitted to isokinetic concentric or eccentric exercise. METHODS: Fourteen male athletes from the U-20 soccer category of a first division Brazilian soccer team (ages 17.75 ± 1.21 years) were randomized into concentric exercise (CON, n = 7) or eccentric (ECC, n = 7) isokinetic exercise groups. The peripheral frequency of CD3+ CCR5 and CD14+ CCR5+ was evaluated before, immediately after, and 24 h after each exercise bout using flow cytometry. RESULTS: Progressive decreases were found in total CCr5 in ECC groups, with significant differences between baseline and 24 h after(p = 0.023). Both ECC and CON groups induced a significant decrease in CCr5 expression on the cell surface of CD14+ monocytes 24 h after bout(p CONCLUSIONS: CCr5 is highly sensitive to physical exercise and the modulation of its expression on cell surface may be related to migration of the cells to damaged tissue.