Efficacy of follitropin delta in potential low responders: a pooled analysis of individual patient data from five randomized controlled trials

Objectives This study evaluated the efficacy of individualized follitropin delta dosing in patients with potential low response, defined by anti-Müllerian hormone (AMH) level Methods A pooled analysis including 1844 patients from five randomized controlled trials was undertaken. The trials selected for the analysis used individualized dosing of follitropin delta, based on AMH level and body weight. Patients with potential low response (AMH screening level Results The mean age was 34.6 years for patients with AMH Conclusions Follitropin delta dosing in young patients with moderately reduced ovarian reserve, using 12 µg/day for ovarian stimulation, demonstrated clinically relevant fresh-cycle pregnancy outcomes as compared to patients with normal or high ovarian reserve. This pooled analysis adds evidence for the efficacy of follitropin delta across all ovarian reserve subgroups of the infertile population. The study was limited to fresh cycle outcomes; further studies are warranted focusing on cumulative outcomes and older patient populations with low ovarian reserve.