Abstract
Objective
The concurrence of anti-contactin-1 (CNTN1) antibody-associated autoimmune nodopathies (AN) and nephropathy has been sporadically reported, though the underlying relationship remains unclear. This case series study aimed to investigate the clinical characteristics and renal pathology of anti-CNTN1 antibody-associated AN with nephropathy.
Methods
A retrospective case series was conducted including 69 patients diagnosed with AN, among whom 11 patients tested positive for anti-CNTN1 antibodies. Clinical manifestations, electrophysiological data, laboratory results, and renal biopsy findings were collected and analyzed. The presence of nodal/paranodal antibodies was confirmed using serum cell-based assays. Renal biopsies were performed in four patients, with immunohistochemical and immunofluorescence staining, including CNTN1 staining, to characterize renal pathology.
Results
Compared to patients with non-anti-CNTN1 antibody-associated AN, the anti-CNTN1 antibody group had a significantly lower proportion of males (54.5% vs. 84.5%,
p
= 0.024) but showed higher rates of hypertension (36.4% vs. 8.6%,
p
= 0.021) and positive autoimmune antibodies (50% vs. 5%,
p
p
p
Conclusion
Anti-CNTN1 antibody-associated AN patients have a higher prevalence of nephropathy compared to those AN without anti-CNTN1 antibodies. Females demonstrate a particularly higher risk of comorbid AN and nephropathy. Renal pathology in these patients is not limited to MN but can also include LN. These findings highlight a complex immunopathological relationship between anti-CNTN1 antibody-associated AN and nephropathy, warranting further studies to understand the underlying mechanisms.