Abstract
Objective
This study aimed to examine the association between post-Intravenous thrombolysis delirium and 90-day functional outcomes in patients with acute ischemic stroke (AIS).
Methods
Patients admitted to the Second Hospital of Jiaxing within 24 hours of symptom onset who underwent intravenous thrombolysis for AIS between January 1, 2023, and December 31, 2024, were retrospectively analyzed. Clinical data were collected to evaluate factors associated with the occurrence of post-reperfusion delirium. Functional outcomes at 90 days were assessed using the modified Rankin Scale, with scores of 0–2 classified as favorable and scores of 3–6 classified as poor. Multivariate logistic regression analyses were performed to identify independent risk factors for the development of post-reperfusion delirium and unfavorable 90-day functional outcomes.
Results
A total of 272 patients were included, comprising 173 males and 99 females, with a mean age of 67.27 ± 11.74 years. Delirium developed in 42 patients, corresponding to an incidence rate of 15.4%. Dysphagia (OR 22.695, 95% CI 9.853 to 52.135, P
Conclusion
Delirium is significantly associated with poor functional outcomes at 90 days in patients with AIS treated with intravenous thrombolysis, highlighting the clinical importance of early delirium detection. Dysphagia, secondary infections, hypoproteinemia, high baseline NIHSS scores, and large-artery atherosclerotic and cardioembolic stroke subtypes are independently associated with both delirium occurrence and adverse 90-day outcomes.