Defending tranexamic acid and sensible scientific clinical trial design

Bruce L. Davidson

doi:10.4081/btvb.2026.405

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Defending tranexamic acid and sensible scientific clinical trial design

Bruce L. Davidson

Bleeding, Thrombosis and Vascular Biology2026doi:10.4081/btvb.2026.405

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Abstract

Three recent clinical trial reports published in the New England Journal of Medicine (NEJM) appear to undermine reputed effectiveness of tranexamic acid (TXA) as a hemostatic drug. They found no value for TXA over placebo as they used TXA, and as they assessed the outcome [...]

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Bruce L. Davidson#1

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External reference records

10.1056/nejm199807233390407

10.1056/nejmoa2207419

10.1056/nejmoa2201171

10.1056/nejmoa2215457

10.1056/nejme2305075

10.1016/s0140-6736(20)30848-5

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