A Comparative Study of Lipid Profile in Chronic Renal Failure Patients on Dialysis

Chronic renal failure (CRF) is characterized by loss of kidney function due to lasting damage to nephrons resulting in decreased estimated glomerular filtration (eGFR) and suppressed urine formation. Disturbance of lipid profile in CRF has been found associated with increased triglycerides (TG) and low high-density lipids while the normal level of total cholesterol (TC) and low-density lipids (LDL). Dislipidemia in CRF patients induces cardiovascular diseases (CVD); in addition, CVD in turn leads to the more rapid destruction of the kidney. Therefore the present study was designed to evaluate the lipid profile in CRF patients with and without dialysis. This was a prospective type of study conducted in the Department of Medicine of a tertiary care centre from July 2019 to December 2019. A total of 100 patients of CRF patients and 40 normal control subjects were recruited for the study. CRF patients were divided into two groups. Group, I consisted of CRF patients with dialysis and group II included CRF patients without dialysis. Normal subjects were kept under a group III control group. The study revealed that there was a significant difference between TG, HDL and VLDL of group I (p>0.01) and group II (p>0.01) in comparison to group III. On the other hand, no significant variation was seen in the TC and LDL levels of the groups mentioned. CRF patients either with dialysis or without dialysis have a great possibility of developing dyslipidemia as well as CVD. Dialysis has been found effective in reducing nitrogenous waste products in the blood; however, it is not able to decrease the lipid profile in CRF patients.