Peculiarities of Cytokine Status and Biochemical Indicators in Bronchial Asthma in Children

The article studies the indicators of the cytokine status and determines the features of the hemostasis system and acid-base state in bronchial asthma in children. We examined 25 children with bronchial asthma in the period of exacerbation at the age from 7 to 14 years, who received treatment in the department of allergology, the comparison group consisted of 20 patients with bronchial asthma in the remission phase, the control group consisted of 10 practically healthy children of the same age. From the side of biochemical parameters, a very low level of prothrombin time, mild metabolic alkalosis, low partial pressure of oxygen in the blood, and a decrease in the concentration of potassium and calcium ions were revealed. This is caused by disturbances in the hemostasis system, due to long-term persistent inflammation in the bronchopulmonary system and severe hypoxia.