Abstract
Diabetes mellitus with hypertension may increase the risk of cardiovascular complications through endothelial dysfunction and increased platelet activity. Mean Platelet Volume (MPV) is a hematological parameter that describes platelet size and activity. This study aimed to analyze the correlation of MPV with HbA1c levels and blood pressure in patients with diabetes mellitus and hypertension at Syarifah Ambami Rato Ebu Regional General Hospital, Bangkalan. An observational analytic study with a cross-sectional design was conducted involving 21 patients selected using purposive sampling from October 2025 to May 2026. MPV was measured using a Sysmex XN-550 Hematology Analyzer, while HbA1c data were obtained from medical records and blood pressure was measured using a digital device. Spearman correlation analysis was used to examine the relationships among variables. The results showed that 15 respondents (71%) had MPV >10.5 fL, with a mean value of 10.7 fL. The mean HbA1c level was 9.7%, while the mean blood pressure was 166/107 mmHg. No significant correlation was found between MPV and HbA1c (p=0.370), systolic blood pressure (p=0.108), or diastolic blood pressure (p=0.336). In conclusion, elevated MPV was not significantly correlated with HbA1c or blood pressure in the studied patients.
ABSTRAK
Diabetes melitus dengan hipertensi dapat meningkatkan risiko komplikasi kardiovaskular melalui gangguan fungsi endotel dan peningkatan aktivitas trombosit. Mean Platelet Volume (MPV) merupakan parameter hematologi yang menggambarkan ukuran dan aktivitas trombosit. Penelitian ini bertujuan menganalisis korelasi MPV dengan kadar HbA1c serta tekanan darah pada pasien diabetes melitus dengan hipertensi di RSUD Syarifah Ambami Rato Ebu Bangkalan. Penelitian menggunakan desain observasional analitik dengan pendekatan cross-sectional. Sebanyak 21 pasien yang memenuhi kriteria inklusi dan eksklusi dipilih menggunakan purposive sampling selama Oktober 2025–Mei 2026. Pemeriksaan MPV dilakukan menggunakan Hematology Analyzer Sysmex XN-550, sedangkan kadar HbA1c diperoleh dari rekam medis dan tekanan darah diukur menggunakan alat digital. Analisis korelasi dilakukan dengan uji Spearman. Hasil penelitian menunjukkan 15 responden (71%) memiliki MPV >10,5 fL dengan rata-rata 10,7 fL. Rata-rata HbA1c sebesar 9,7% dan tekanan darah sebesar 166/107 mmHg. Tidak terdapat korelasi signifikan antara MPV dengan HbA1c (p=0,370), tekanan darah sistolik (p=0,108), maupun diastolik (p=0,336). Disimpulkan bahwa peningkatan MPV tidak berkorelasi signifikan dengan HbA1c maupun tekanan darah pada kelompok pasien yang diteliti.