Abstract
Regional science has a variety of characteristics that distinguish it from its sister social sciences: it works the boundaries of economics, geography, planning studies, and sociology; space is its focus; spatial dependence is a core concern; comparative advantage remains a key concept for understanding how space will develop. Facing new and old challenges from global competition, lagging regions of the U.S., and especially in the rural South, will need new ideas from regional science on how to fit into the emerging economy in ways that promote higher incomes across all deciles of the income distribution.
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