Abstract
Objective To explore the mediating effect of fear of disease progression between social support and acceptance of illness in patients with colorectal cancer. Methods Using the convenience sampling method, a total of 213 colorectal cancer patients who met the inclusion criteria were recruited from the Anorectal Surgery and Colorectal Surgery Departments of the Sixth Affiliated Hospital of Sun Yat-sen University from August 2025 to December 2025. The General Information Questionnaire, Acceptance of Illness Scale (AIS), Social Support Rating Scale (SSRS), and Fear of Progression Questionnaire-Short Form (FOP-Q-SF) were adopted to conduct the questionnaire survey. Results The score of AIS in colorectal cancer patients was (22. 12±7. 17), the score of FOP-Q-SF was (35. 04±10. 06), and the score of SSRS was (41. 56±8. 46). Illness acceptance was negatively correlated with fear of disease progression (r=-0. 379, P＜0. 01) and positively correlated with social support (r=0. 282, P＜0. 01). Fear of disease progression played a partial mediating role between social support and illness acceptance in colorectal cancer patients, with the mediating effect accounting for 20. 97% of the total effect. Conclusion Fear of disease progression plays a partial mediating role between social support and acceptance of illness in patients with colorectal cancer. Clinical medical staff should attach importance to the construction of patients’ social support systems, and conduct targeted psychological interventions on fear of disease progression, so as to enhance patient’s disease acceptance, help them cope with the disease better, re-adapt to society, and improve their quality of life. (目的 探讨恐惧疾病进展在结直肠癌患者社会支持与疾病接受度间的中介效应。方法 采用便利抽样法选取2025年8月—12月中山大学附属第六医院肛肠外科、结直肠外科符合纳排标准的213例结直肠癌患者作为调查对象。采用一般资料调查表、疾病接受度量表(AIS)、社会支持评定量表(SSRS)、癌症患者恐惧疾病进展简化量表(FoP-Q-SF)对其进行问卷调查。结果 结直肠癌患者疾病接受度得分为(22. 12±7. 17)分、恐惧疾病进展得分为(35. 04±10. 06)分、社会支持得分为(41. 56±8. 46)分。结直肠癌患者疾病接受度与恐惧疾病进展呈负相关(r=-0. 379, P＜0. 01), 与社会支持呈正相关(r=0. 282, P＜0. 01)。恐惧疾病进展在结直肠癌患者社会支持与疾病接受度间起部分中介作用, 中介效应占总效应的20. 97%。结论 恐惧疾病进展在结直肠癌患者社会支持与疾病接受度间起部分中介作用。临床医护人员应重视患者社会支持系统构建, 同时针对性开展恐惧疾病进展心理干预, 以提高患者对疾病的接受度, 帮助其更好地面对疾病, 重新适应社会并提高生活质量。)