Abstract
Diabetes is a global metabolic disease that affects millions of individuals worldwide and raises the global death rate, posing a public health concern. Because antidiabetic traditional drugs are expensive, have side effects, and are ineffective, researchers are looking into novel medicinal plants to find a long-term cure that is inexpensive, has few or no side effects, and is highly effective in treating diabetes and its consequences. Detarium senegalense is a versatile plant used to cure a variety of ailments, including diabetes. This research aimed to investigate the ameliorative potentials of methanol bark extract of Detarium senegalense in streptozotocin-Induced Diabetic male Wistar Rats. Thirty (30) adult male Wistar rats weighing 120-180gm were chosen at random and put into six (6) groups of five rats each (n=5) for this investigation. A single intraperitoneal injection of streptozotocin (150mg/kg) produced diabetes in rats. Normal and diabetic control groups are represented by groups 1 and 2, respectively. Group 3, a diabetic group, received metformin (50mg/kg). Groups 4, 5, and 6 received methanol bark extract of Deterium senegalenses at 250, 500, and 1000 mg/kg/day, respectively. The animals were euthanized at the end of the 21-day treatment period, and organs were excised for biochemical examination. The generated data was analyzed with the SPSS software, and the results were expressed as mean SEM. Result confirms Detarium senegalense methanol bark extract as a hypoglycemic agent on the diabetic rats, by decreasing blood glucose level and the activity of metabolic enzymes (α-amylase and α-glucosidase), increase hexokinase, Superoxide dismutase, Catalase, Glut 1 and Glut 2 activities while decreasing the activities of Malondialdehyde. Conclusively, the bark of Detarium senegalense has been shown to have anti-diabetic and anti-oxidative.