Abstract
Hyaluronic acid is one of the most used substances in dermatology. It presents structural roles in the extracellular matrix, binding to cells and biological components through specific and nonspecific interactions. The native ligand for hyaluronic acid is the transmembrane CD44 receptor, which interacts not only with hyaluronic acid but also with different growth factors, cytokines, and extracellular matrix proteins. We seek to review the interaction of the CD44 receptor with the various forms of hyaluronic acid in the skin to better understand its action and fully explore its use in dermatology.