Abstract
Microneedling has traditionally been used to induce collagen formation. Scalp
microneedling has been seen to stimulate the capillary cycle and anagen phase,
but studies demonstrating histopathological changes after this procedure are
lacking. Here we present the case of a 37-year-old woman with a 15-year history
of female pattern alopecia, with diffuse hair thinning prominent in the
frontoparietal region and hair miniaturization seen in dermoscopy. The
patient’s condition remained stable for seven years with use of
spironolactone and topical minoxidil. The patient underwent three scalp
microneedling sessions at monthly intervals. Histopathological analysis was
conducted before the sessions and one month after the last session. Despite
slight clinical and dermoscopic improvement, the alopecia pattern remained the
same, without significant changes in follicle count after the interventions.
Neither inflammation nor fibrous tracts were observed after the procedure. The
histopathological analysis is essential to assess the safety of scalp
microneedling in the short and long term, investigate signs such as inflammation
and fibrosis, and determine the effectiveness of this procedure in treating
alopecia. Studies with a more significant number of cases are necessary.