Abstract
Introduction: Plant extracts and actives derived from plants were developed to improve and
enhance the skin healing process including Triticum aestivum L.
(Triticum vulgare).
Purpose: To evaluate the effect of whole grain extract (EGTA-PR) and aqueous extract
(EATA-FI) of Triticum aestivum L., on ex vivo skin
healing.
Methods: Skin fragments obtained from elective plastic surgery were subjected to
tissue damage and treated with extracts for eight days for histological
evaluation of re-epithelialization and immunofluorescence for epidermal
growth factor (EGF).
Results: EGTA-PR and EATA-FI accelerated the re-epithelialization process in human
skin culture submitted to tissue injury. Additionally, we observed increased
EGF protein labeling after treatment with EGTA-PR.
Conclusion: EGTA-PR showed a better performance in re-epithelialization when compared to
EATA-FI, as it presented a higher protein labeling for EGF in human skin
culture. Likewise, the histological results showed that the dermal
redensification obtained with EGTA-PR was visually superior to that observed
with EATA-FI. The results obtained are promising and corroborate the several
biological actions already reported in the literature for Triticum
aestivum L. extract in tissue healing stages.