Abstract
Background: Pyoderma gangrenosum is a rare neutrophilic dermatosis with very low incidence and varied clinical presentation associated with different comorbidities. It is also a diagnostic-therapeutic challenge. Clinical case: A 79-year-old woman presented 18 months of dermatosis evolution that began as a perianal pustule and progressed to a 20 cm in diameter ulcer. Due to her comorbidities, she received topic treatment with satisfactory evolution. Conclusions: Pyoderma gangrenosum is frequently associated with a systemic disease. Consequently, it must be approached from a systemic perspective with the support of a multidisciplinary team to provide the most appropriate treatment.