Abstract
This study compared the effectiveness of secretome delivery using microneedling versus laser-assisted drug delivery for facial skin rejuvenation. The review included seven studies that demonstrated that both approaches were effective in delivering secretomes. However, microneedling had a higher patient satisfaction rate and fewer reported adverse events. We concluded that micro needling may be a more patient-friendly and safer option for facial rejuvenation. Further studies with larger sample sizes and extended follow-up periods are needed to confirm these results.