Eficácia e segurança de solução de fenol 85% e óleo de cróton 4% no tratamento das verrugas anogenitais do pênis: um estudo tipo prova de conceito

Introduction: An 85% phenol and 4% croton oil solution (SFC) has cytotoxic effect on the epithelium; however, it has not been evaluated in the treatment of anogenital warts (AGW). Objective: To evaluate the effectiveness of SFC in the treatment of penile AGW in immunocompetent patients. Methods: Open, uncontrolled clinical trial (proof-of-concept), involving patients with penile AGW treated with SFC and reevaluated after 28 days. RESULTS: We evaluated 16 treatments in 9 participants. SFC promoted total clearance of the lesions in 25% (95% CI 2-48%) of treatments. Conclusions: Although well tolerated, SFC caused insufficient rates of total clearance.